Verletzung umbilical Blutfluß

vascular implants



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Verwendung von vegf zur herstellung eines medikaments zur behandlung oder verhinderung der intimalen hyperplasie und verabreichungsgerät Use of VEGF for the manufacture of a Birkenteer Varizen for the treatment or prevention of intimal hyperplasia and administration device translated from German DE T2.

Use according to claim 1, wherein the blood vessel is an artery. Verwendung nach Anspruch 1 oder 2, zur Behandlung oder Prävention einer Stenose, die durch einen operativen Eingriff hervorgerufen wurde oder mit einer Pulmonal-Arteriellen Hypertension verbunden ist.

Use according to claim 1 or 2, for the treatment or prevention of stenosis induced by a surgical procedure or associated with a pulmonary arterial hypertension. Verwendung nach Anspruch Verletzung umbilical Blutfluß, in welcher es sich beim operativen Eingriff um Angioplastie, koronare Bypass-Operation, Verletzung umbilical Blutfluß, operative Anastomose oder Endarteriektomie handelt.

Use according to claim 3, Verletzung umbilical Blutfluß, in which it is the surgery to angioplasty, coronary bypass surgery, surgical anastomosis or endarterectomy, Verletzung umbilical Blutfluß. Use according to one of the preceding claims for treating or preventing stenosis of blood vessels. Use according to one of the preceding claims for the treatment or prevention of restenosis of blood vessels.

Verwendung nach einem der vorstehenden Ansprüche, Verletzung umbilical Blutfluß welcher der Wirkstoff eine Nukleinsäure in Verbindung mit einem trophischen Geschwüren mit Krampfadern der unteren Extremitäten oder nicht-viralen Vektor ist.

Use according to one of the preceding claims, in which the active substance is a nucleic acid in association with a viral or non-viral vector. An implant for therapeutic use, which is so designed that it, on or close to the point which is placed to be treated or preventing intimal hyperplasia in which the endothelium is wholly or largely intact, and containing an active substance according to any one of the preceding claims.

Ein Implantat nach Anspruch 9, das ein Silastik-Implantat oder ein biologisch abbaubares Implantat ist. An implant according to claim 9, which is a silastic implant or a biodegradable implant.

An implant according to claim 9 or 10 in the form of a sleeve which is adapted to be treated or prevented by hyperplasia in a blood vessel at or near the site.

An implant according to any one of claims 9 to 11, whose outer wall is impermeable to the active substance contained in it substantially. Use according to any one of claims 1 to 8, for use in the feeding of Laser-Entfernung von Krampfadern in Lipetsk active substance into a blood vessel in a patient, wherein the active ingredient is provided in a carrier which is adapted to ensure a seal around the vessel, wherein the active ingredient in the device is held or connected thereto, so that it comes in use into contact with the adventitial surface.

Die vorliegende Erfindung betrifft die therapeutische Verwendung eines vaskulären endothelialen Wachstumsfaktors, insbesondere zur Behandlung und Prävention der Intimahyperplasie von Blutgefässen und anderer Zustände, Verletzung umbilical Blutfluß, insbesondere Bluthochdruck. The present invention relates to the therapeutic use of a vascular endothelial growth factor, particularly for the treatment and prevention of intimal hyperplasia Verletzung umbilical Blutfluß blood vessels and other conditions, especially hypertension.

Die Erfindung betrifft auch eine Vorrichtung, die für die Verabreichung des aktiven Verletzung umbilical Blutfluß verwendet werden kann. The invention also relates to a device which can be used for administration of the active agent. Hintergrund der Erfindung Background of the Invention. Intimahyperplasie ist die Zunahme der Zellzahl zwischen dem Endothel und der Lamina elastica interna eines Blutgefässes, insbesondere in der dortigen Endothelschicht Intima oder in einer Arterie.

Intimal hyperplasia is the increase in cell number between Verletzung umbilical Blutfluß endothelium and internal elastic lamina of a blood vessel, in particular in the local endothelial lining intima or in an artery.

Intimal hyperplasia is often caused by smooth muscle cell proliferation in the blood vessel wall. When intimal hyperplasia occurs, this can lead to a de novo thickening of the endothelial or vascular wall, ie stenosis.

This allows the blood vessels are closed. Also, if a restriction Verletzung umbilical Blutfluß been eliminated in a blood vessel, perform a postoperative intimal hyperplasia occurring to the Verletzung umbilical Blutfluß that the artery closes again, Verletzung umbilical Blutfluß. Dies ist als Restenose bekannt. This is known as restenosis. A proliferation of arterial smooth muscle cells commonly occurs when a blood vessel, for. Example an artery, Verletzung umbilical Blutfluß, is deformed or destroyed during a surgical procedure.

Zum Beispiel kann eine Intimahyperplasie zur De-novo-Stenose infolge von Bypassgrafts führen, in welchen eine Vene mit einer Arterie verbunden wird, und allgemein infolge chirurgischer Anastomose. For example, intimal hyperplasia to de novo stenosis as a result of bypass grafts result in which a vein with an artery is connected, and generally as a result of surgical anastomosis. Zwei Beispiele von chirurgischen Eingriffen, die zu Stenose führen können, sind koronare Bypassgrafts und femoro-popliteale arterielle Oberschenkel-Bypassgrafts.

Two examples of surgical procedures that can lead to stenosis, coronary artery bypass grafts and are femoro-popliteal arterial femoral bypass grafts. Ähnlich kann Restenose infolge von Ballonangioplastie-Verfahren auftreten, die dazu verwendet werden, Verengungen in Blutgefässen zu beseitigen, beispielsweise Ballonangioplastie-Verfahren. Similarly, restenosis may occur as a result of balloon angioplasty procedures used to eliminate constrictions in blood vessels, such as balloon angioplasty procedures.

Intimahyperplasie, ob sie zu Stenose oder zu Restenose führt, bleibt ein Hauptproblem nach unterschiedlichen chirurgischen Verfahren. Intimal hyperplasia, whether it leads to stenosis or restenosis, remains a major problem after various surgical procedures.

Atherosclerotic cardiovascular disease is the leading cause of death in Europe and North America Verletzung umbilical Blutfluß cause a highly significant morbidity due to occlusion of the arterial lumen, blood flow either preventing or inhibiting, a plaque with superimposed thrombosis with possible distal embolization, weakening of the arterial wall leading to the aneurysmal expansion and possibly to Rupture lead. Abhängig von Lokalisation und Krankheitsverlauf existieren mehrere Behandlungsmöglichkeiten, mit dem arteriellen Bypassgraft als den geläufigsten chirurgischen Eingriff.

Depending on the location and course of the disease, there are several treatment options, with the arterial bypass graft as the most common surgical procedure. In the aorta, renal vessels, mesenteric and peripheral vessels increases the burden of surgical bypass procedures with surgery rates in the United States and Europe by perinhabitants continuing. Zusammen beträgt die Zahl der jährlich vorgenommenen chirurgischen Bypassverfahren annähernd eine Million.

Together, the number of surgical bypass procedures undertaken annually is approximately one million, Verletzung umbilical Blutfluß. In the first 24 months after surgery suggests a very significant number of arterial bypass grafts fail Seal. This means that for all made annually in the UK cardiac and peripheral arterial bypass procedures may be expected approximately Die Fehlschlagrate bei Wiederholungsverfahren liegen sogar noch höher. The failure rate for repeat procedures are even higher.

There are three main reasons why grafts fail within five years after surgery. Späteres Fehlschlagen, nach 24 Monaten, ist hauptsächlich das Ergebnis eines Fortschreitens des ursprünglichen Arterioskleroseprozesses, Verletzung umbilical Blutfluß. Later failure, after 24 Verletzung umbilical Blutfluß, is mainly the result of progression of atherosclerosis original process. In these cases, it is SMC intimal hyperplasia one Verletzung umbilical Blutfluß is responsible for progressive narrowing, z.

Typically, the SMC intimal hyperplasia at the distal arterial anastomosis and the native vessel wall is located opposite the anastomosis. Es handelt sich somit um eine primäre Pathologie an dieser Stelle und nicht um eine Restenose an der Stelle einer vorhergehenden Intimahyperplasie, wie es infolge Angioplastie der Fall sein kann. It is thus a primary pathology at this site and not restenosis at a site of previous intimal hyperplasia as might be the case as a result of angioplasty.

SMC-Intimahyperplasie kann an der proximaleren arteriellen Anastomose und entlang dem Graft selbst auftreten.

SMC intimal hyperplasia can occur even in the more proximal arterial anastomosis and along the graft. Stenose und Restenose stellen weiterhin beide bedeutende Probleme nach chirurgische Eingriffen dar.

Stenosis and restenosis continues to provide both significant problems is by surgical intervention. Heutzutage sind zahlreiche Methoden zur Behandlung und Prävention der Intimahyperplasie getestet Verletzung umbilical Blutfluß, aber keine war klinisch zufriedenstellend. Today, numerous methods have Verletzung umbilical Blutfluß tested for the treatment and prevention of intimal hyperplasia, Verletzung umbilical Blutfluß, but none were clinically satisfactory. Vascular endothelial growth factor VEGF is a naturally occurring protein.

Beim Menschen kommen mindestens vier Formen mit, Verletzung umbilical Blutfluß, und Aminosäuren vor. In humans at least four forms occur with, and amino acids. Eine genomische Teilsequenz ist auch gegeben.

A partial genomic sequence is also given. It should be understood that this numbering refers to the number of each amino acid of the mature protein. The translated protein also includes a presequence of 26 amino acids that is naturally cleaved during intracellular processing, Verletzung umbilical Blutfluß. VEGF is known to play a role in angiogenesis, where the division of vascular endothelial cells EC stimulates increased endothelial permeability and acts as an endothelial "survival factor" in retinal vessels.

Beispielsweise kann VEGF in rekombinanter Form oder wenn von einem Vektor exprimiert die Entwicklung neuer Blutgefässe induzieren, wenn es intraarteriell in ischämische Extremitäten injiziert wird. For example, VEGF can induce, when injected intra-arterially into ischemic limbs in recombinant form or when expressed from a vector, the development of new blood vessels.

Diese Eigenschaft hat zu seiner Verwendung bei der Reparatur von Arterien geführt, deren Endothele während chirurgischer Eingriffe verletzt wurden. This property has led to its use in repairing arteries whose endothelia have been damaged during surgery. So haben Asahara et al. It was found that VEGF stimulated the Verletzung umbilical Blutfluß of the artery which, in turn, appeared to contribute to suppression of intimal hyperplasia.

VEGF protein and gene are disclosed in WO-A, and their use for the treatment of injuries to the vascular epithelium, diabetic ulcers and injuries of blood vessels have been proposed. VEGF fragments are described in WO-A, Verletzung umbilical Blutfluß, and their use in angiogenesis and re-endothelialization of inner vascular walls, such.

As in the treatment of ulcers. GB-A discloses a non-restrictive porous outer stent for arteriovenous bypass graft procedures. This Verletzung umbilical Blutfluß has beneficial effects on lumen size and media and intimal thickening. WO-A discloses a device for local administration of a substance in a blood vessel, comprising a reservoir formed between two of its elements.

Their use requires implantation, ie cutting through the vessel and then securing the device to the vessel walls. Die Vorrichtung ist teilweise porös. The device is partially porous. The reservoir is in direct contact with the blood flow in the lumen. Dies birgt das Risiko einer Infektion. This carries the risk of infection. US-A discloses a device for administering a drug to the adventitia of Tinktur aus Walnuss von Krampfadern blood vessel, Verletzung umbilical Blutfluß.

Sie ist mit permanenten Wänden und transkutanen Sonden ausgestattet für die Verabreichung von Medikamenten in flüssiger Form. It is provided with permanent walls and transcutaneous probes for the administration of medicaments in liquid form.

The aim is that the drug should go to a different place. Zusammenfassung der Erfindung Summary of the Invention. Surprisingly, properties of VEGF have been identified, suggesting that it can be used in various ways against intimal hyperplasia. A cuff was placed around the outside a rabbit artery. This procedure usually causes intimal hyperplasia in the rabbit artery, leading to thickening of the arterial wall, which is comparable to the stenosis that can occur in human arteries following bypass operations.

Eine Intimahyperplasie wurde unterdrückt. Intimal hyperplasia was suppressed. Verletzung umbilical Blutfluß has been shown that the Adventitiamanschette is suitable for arterial gene transfer with all tested gene delivery systems.


DEC2 - vascular implants - Google Patents Verletzung umbilical Blutfluß

The invention relates to implants that when He set for natural blood vessels used in the body for the supply of arterial blood to organs and tissues throughout the body who the. In particular, these implants, vascular grafts, which are used for the supply of blood to the tissue. Inborn errors, an illness or injury can make the blood vessels of a person unfit to serve as a suitable cable paths for the blood. Autogenous blood vessels can be moved from their original location in the body of the person and transplanted to replace diseased or traumatisier te natural vessel.

It can also be implanted synthetic or derived from a non-autogenous tissue vascular grafts a Verletzung umbilical Blutfluß to replace a diseased or damaged natural vasculature. Infection, aneurysm, thrombosis, hyperplastic tissue reaction, narrowing the vessel connections are among the problems that occur in all known vascular grafts, whether these autogenous or non-autogenous origin.

The long-term patency of vascular Trans plan did depend on many factors including the skill of the implanting surgeon, the patient's health, the quality of the vascular graft as well as to broader factors. The influence of a special Fak tors to a successful long-term function has not been quantified, Verletzung umbilical Blutfluß.

However, it is generally ausgegan it gen that a low velocity of blood flow and a low flow rate are the main factors that reduce the patency. For coronary revascularization autogenous saphenous vein is used as a vessel ladder successfully. Obwohl die Suche nach einem geeigneten prosthetischen Implantat für einen aortocoronären Bypass anhält, ist nichts besseres als die autogene Vena saphena verfügbar. Verletzung umbilical Blutfluß the search for a suitable prosthetic implant lasts for a aortocoronären bypass, nothing is better than the autogenous saphenous vein available.

Die Chirurgen haben die Verwendung synthetischer Im plantate als aortocoronärer Bypass abgelehnt, da nur wenig nachgewiesene Beispiele für ein langdauerndes Offenbleiben existieren. The surgeons have to use synthetic rejected because little documented examples of a long-lasting patency exist in implants as aortocoronärer bypass.

Obwohl Wadenvenen Vena saphena bei aortocoronären By pass-Verfahren verwendet werden, weisen sie bestimmte Nachteile auf: Although Wade veins saphenous vein are used in aortocoronären By pass procedures, they have certain drawbacks: A significant number of patients who need a coronary bypass coronären, Verletzung umbilical Blutfluß, do not have suitable veins or the veins have already been used for previous aortoco ronäre bypass or peripheral vascular bypass procedures.

It can not have been foreseen even before surgery occasionally that a transplant is needed, and the legs were not prepared for the extraction of the vein. Die Vena cephalica aus dem Arm wurde verwendet, wenn die Vena saphena nicht verfüg bar ist. The cephalic vein from the arm was used when the saphenous vein is not availabl bar. Sie ist jedoch normalerweise dünnwandig und häufig von einem schlechten Kaliber, Verletzung umbilical Blutfluß.

However, it is usually thin-walled and often of poor caliber. In addition, the cosmetic effect of obtaining the cephalic vein for some patients is not acceptable. The Verletzung umbilical Blutfluß mammary artery is akzep advantage in a large scale as suitable for myocardial revascularization, since it has an excellent remaining open ratio, however, is suitable only for the left anterior abstei constricting and the diagonal coronäre artery, Verletzung umbilical Blutfluß.

Die Erfahrung mit freien Transplantaten aus internen Brust drüsen- und radialen Arterien war enttäuschend, da das Langzeit-Offenbleiben schlecht war. Experience with free grafts from internal breast glandular and radial artery was disappointing as the long-term patency was Krampfadern Vagina mit Fotos. Die Bedeutung der Strömungsgeschwindigkeit des Blutes in autogenen Venen-Transplantaten wurde hervorgehoben.

The importance of blood velocity in autogenous vein grafts was emphasized. There is evidence of an inverse relationship between the flow rate of the blood in veins th Trans-Planta and the observed extent of intimal proliferation. Autopsy studies show that a closure of aortoco ronären saphenous vein grafts is Verletzung umbilical Blutfluß more than 1 month after surgery most often by a fibrous In tima proliferation.

Although the reason for this damage is not definitely proven, indicate studies that these are likely to be linked with a ge wrestle flow through the graft ver. Patents 3,; 3 und 3 alle Liebig beschrieben. Diese Im plantate sind langgestreckte gewirkte Gewebs-Rohre aus einem Garn wie beispielsweise Polyesterfasern. These are elongated knitted tissue tubes from a yarn, such as polyester fibers in the implants. The US Patents 3, and 3, both Dardik describe the use of umbilical cords implants as vascular Trans.

Also in the US Patent 4, Holman a process for the preparation of human or animal umbilical cords for use is described as a vascular replacement, Verletzung umbilical Blutfluß. Die US-Patentschrift 2 beschreibt Rohre aus absorbierbaren tierischen Materialien, die als Implantate für verschiedene Zwecke dienen sollen. The US patent 2, describes tubes of absorbable animal materials to serve as implants for various purposes. Die oben genannten Geweberohre und Nabelschnüre wurden Verletzung umbilical Blutfluß verwendet, Vena-saphena-Implantate zu ersetzen.

The fabric tubes and umbilical Salbe Sternchen von Krampfadern above were used to replace saphenous vein implants, Verletzung umbilical Blutfluß. Die Enden der Röhren und Nabelschnüre werden an die Enden von Arterien anastomosiert, um erkrankte Abschnitte der Arterien zu umge hen. The ends of the tubes and umbilical cords are anastomosed to the ends of arteries to hen diseased portions of the arteries to be converted.

Sie ersetzen dadurch die erkrankten Bereiche der Arte rien. Such a method may be additionally reinforced with the implants by an outer wrapper web is described in US Patent 3, Diese beschreibt Implan tate in Form von rohrförmigen Bypässen, die von Blut durch strömt werden und deren Enden mit Blut liefernden bzw. This describes Implan tate be connected in the form of tubular bypasses which are flows of blood through and providing the ends with blood or blood-receiving blood vessels.

Als Rohrkörper können z. As tubular body such can. The US Patent 3, describes a tubular In Plantat that is to serve the supply of cardiac muscle with arterial blood, wherein the tubular body has no open outlet end. The provided with small lateral openings terminal branches of the implant have closed ends and are sewn into the heart wall, so that blood vessels can grow. The goal of a reconstructive vascular surgery is to provide an efficient manner in organs and tissues with blood, in which the integrity of the blood vessels be due to congenital or acquired disorders such as errors example as arteriosclerosis, trauma, or other diseases is impaired.

The invention did in a Implan which enables the supply of organs and tissues throughout the body with blood. According to the present invention, an implant for supplying one or more blood receivers, such as blood vessels is provided with blood. In the Verletzung umbilical Blutfluß comprises an elongated member having a con tinuous passage opening for the transfer of blood from a pressurized blood supply to one or more blood receivers.

Das langgestreck te Element weist einen Rumpf auf, der eine erste Durch gangsöffnung für die Überführung von Blut schafft. The more elongated th Verletzung umbilical Blutfluß has a hull that first creates a through-opening for the transfer of blood. The hull has one or more openings and can be connected with at least one blood vessel for supplying the orifice of the blood vessel with blood.

The hull has an inlet-side member which Verletzung umbilical Blutfluß designed to be connected to a pressurized blood supply to the who, whereby the Krampfadern ohne Operation kann sein flows into the first passage opening and out of the first through opening in the blood vessel.

Blood flow and the pressure of the blood in the first passage opening is controlled by means of a member having a narrowed second Durchgangsöff voltage, which is connected to the distal portion of the body which is ent removed from the inlet-side member.

An outlet-side connecting element, the ele ment with the element Verletzung umbilical Blutfluß the narrowed second port with the blood receiving element. A pressure differential between the blood supply element and the blutempfangenen element maintains continuous and adequate blood flow of a desired pressure and a desired speed by the first and the two te passage opening upright and provides a continu ous supply of blood vessels, Verletzung umbilical Blutfluß, which are connected to the body with blood.

Das Implantat wird vorzugsweise dazu verwendet, Blut einem oder mehreren Coronararterien-Zweigen in einem Primatenherzen zuzuführen. The implant is preferably used to supply blood to one or more coronary artery branches in a primate heart.

Such a heart has two atria for receiving blood from the vena cava and the pulmonary veins and is connected to an aorta, Verletzung umbilical Blutfluß, the blood dissipates under pressure from the heart.

The Verletzung umbilical Blutfluß includes an elongated tubular member having a continuous elongated passageway opening for the transfer of blood from the aorta to the atrium or a low pressure blood vessel, Verletzung umbilical Blutfluß. The tubular element has an inlet end which is anastomosed to the aorta, so that blood flows un ter pressure from the aorta in the through hole, and is discharged as the aorta through an outlet in the atrium or other blood vessel with a lower average pressure, Verletzung umbilical Blutfluß.

The outlet end of the tubular ele ments is anastomosed with the heart tissue to a communi nizierende with the atrial opening. Das rohrförmige Element weist eine oder mehrere Öffnungen auf, die dazu verwendet werden, Blut einer oder mehreren Coronararterien oder -zweigen zuzuführen. The tubular member has one or more openings which are used to blood one or more coronary arteries or to supply twigs.

The coronary arteries are sutured to the tubular member so that blood voltages by Publ flows into the tubular element in the Coronararterien- branches. The flow rate, Verletzung umbilical Blutfluß, the Strömungsgeschwin speed and the pressure of the blood in the through hole is controlled by a constriction which is disposed remotely from the inlet end of the tubular member.

Der Be reich der Einschränkung ist eine verengte zweite Durchgangsöffnung mit einem Durchmesser, Verletzung umbilical Blutfluß, der geringer ist als die Hälfte des Durchmessers der Haupt- oder Verletzung umbilical Blutfluß Durchgangsöffnung des rohrförmigen Elements. The restricted inserted through hole is further smaller than the passage opening at the outlet end of the tubular member, Verletzung umbilical Blutfluß. Das rohrförmige Element ist im allgemeinen U-förmig und umgibt die kritischen Bereiche des Herzens kreisförmig, beginnend an der Aorta und endend entweder am rechten oder linken Vorhof oder der Pulmonalarterie.

The tubular member is generally U-shaped and surrounds the critical areas of the heart circular, starting at the Aorta and ending at either the right or left atrium or the pulmonary artery. Der Druckun terschied zwischen der Aorta und dem Vorhof führt zu einem kontinuierlichen Strom an Blut in solchen Mengen und mit solchen Geschwindigkeiten, die eine Thrombose verhin dern, Verletzung umbilical Blutfluß, und schafft eine kontinuierliche Versorgung der mit dem rohrförmigen Element verbundenen Arterien mit Blut eines gewünschten Drucks.

The Druckun terschied between the aorta and the atrial leads to a continuous flow of blood in such amounts and at such rates, the countries verhin thrombosis, and provides a continuous supply of the connected to the tubular member arterial blood with a desired pressure.

Bei einer Ausführungsform der Erfindung ist das rohrförmi ge Element ein langgestrecktes synthetisches Rohr wie beispielsweise ein Polytetrafluorethylen-Rohr, ein Dacron- Rohr Verletzung umbilical Blutfluß ein Rohr aus einem anderen synthetischen bio kompatiblen Material.

In one embodiment of the invention the rohrförmi ge element Verletzung umbilical Blutfluß an elongated synthetic pipe such as a polytetrafluoroethylene tube, a Dacron tube, or a tube of other synthetic bio-compatible material. The tube is continuous and has proximal to its distal or outlet end a portion of reduced diameter.

Der Abschnitt mit vermindertem Durchmesser bildet eine Verletzung umbilical Blutfluß Durchgangsöffnung zur Steuerung des Blutflusses und zur Aufrechterhaltung des Drucks des Bluts in der ersten Durch gangsöffnung des rohrförmigen Elements.

The reduced diameter portion forms a restricted passage for controlling the flow of blood and to maintain the pressure of the blood in the first through hole of the tubular member.

The restricted passage also controls the flow rate and the Ge speed of the blood that moves through the outlet end of the tubular member.

Bei einer zweiten Ausführungsform der Erfindung wird eine menschliche Nabelschnur oder ein anderes Gewebe-Rohr be Verletzung umbilical Blutfluß Ursprungs als langgestrecktes Element verwendet. In a second embodiment of the invention, a human umbilical cord or other fabric tube be arbitrary origin is used as the elongate member. The umbilical cord can be linear or be shaped so that it gives the critical areas of the heart in a circle around.

The outlet portion or distal end portion of the cord has a reduced diameter to provide a restricted passage for the flow of blood through the cord. Ausgewählte Arterien werden an den Rumpf der Verletzung umbilical Blutfluß anastomosiert und sind mit Öffnungen versehen, durch die Blut aus dem Lumen der Schnur in die Arterien strömen kann. Selected arteries are anastomosed to the body of the cord and are provided with openings, can flow into the arteries through which blood from the lumen of the cord.

In a third embodiment of the present invention, the elongated tubular member an autogenous saphenous vein comprises having a caliber of from reaching size in Verletzung umbilical Blutfluß to ensure an adequate blood flow.

Die Vene umgibt das Herz von der Aorta kreisförmig und erstreckt sich bis zu dem Vorhof. The vein surrounding the heart of the aorta circular and extending to the atrium. Die eingeschränkte Durchgangsöffnung steuert den Blutstrom in der Venen-Durch gangsöffnung, während ein kontinuierlicher Blutstrom eines gewünschten Drucks aufrechterhalten wird. The restricted passage controls the flow of blood into the vein through hole, Verletzung umbilical Blutfluß, while a continuous blood flow of Verletzung umbilical Blutfluß desired pressure is maintained.

Ausgewählte Ab schnitte der Vene sind an Coronararterien anastomosiert, um einen kontinuierlichen Blutstrom zu diesen Arterien zu schaffen. Selected from sections of vein are anastomosed to the coronary arteries to provide a continuous flow of blood to these arteries. According to a fourth embodiment of the invention, an implant for the supply of one or more blood receivers, Verletzung umbilical Blutfluß, such as blood vessels is provided with blood.

The implant includes an elongated tubular member having a continuous passage for the transfer of blood from a pressurized blood supply to one or more Faessen Bloody and blood-receiving elements. The blood stream, the velocity of the blood flow and the pressure of the blood in the continuous passage opening is controlled with a reinforced member having a restricted passage and removed with the distal portion of the elongated tubular member is connected by the inlet-side end.


Nabelhernie mit intraperitonealem Netz offen chirurgisch (Ventralex-Patch)

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